The main focus at London Movement Disorder Research Centre is to translate wearable health data to a clinically relevant information to guide physicians in treating their patients better. Interested researchers with scholarships should contact Dr. Mandar Jog at email@example.com with subject heading “Hiring for Projects at LondonMDC”.
Projects Relating To Animal Behavioural and Postoperative Electrophysiology
The primary goal of this project is to understand the function of the motor control system in an established Parkinson disease (PD) rodent model using multi-channel electrodes. This includes studying the reticular formation, its connections and the role of these long tracts in controlling gait.
Projects Relating To Human Intraoperative and Postoperative Electrophysiology
A) In this DBS-PD project simultaneous intraoperative recordings of neurons in the subthalamic nucleus (STN) and of field potentials from motor cortex are obtained to allow us to understand the role STN has while patients perform cognitive and motor tasks.
B) A parallel project is studying long-term field potentials from STN recordings in PD patients post DBS surgery. Patients will perform activities of daily living while real-time LFP data is collected.
Projects Relating To Neuromodulation and Wearable monitoring devices
A) Post-surgical neuromodulation programming in PD patients is a challenge for neurologists. Extensive biomechanical data are being collected and studied in order to understand the impact of these settings on all aspects of mobility and activities of daily living.
B) Based off our pilot work we are studying the use of ambulatory VR scenarios to assess full body mobility and cognitive dysfunction in PD patients. Our second goal which is to also develop a rehab program using VR wearables to train patients to improve their activities of daily living.