The main focus at London Movement Disorder Research Centre is to translate medical research into clinically relevant therapeutic and diagnostic tools that guide physicians in treating their patients better. Interested researchers should email Dr. Mandar Jog with the subject title “Graduate Training and Fellowships at LondonMDC”. Likewise, Dr. Jog offers fellowship training in movement disorders which include procedural training for Deep Brain Stimulation and Botulinum Toxin Therapy. At the end of your training, you will have the skillset to understand what it takes to innovate, translate, and commercialize medical research within the field of neuroscience.
Projects Relating To Animal Behavioural and Postoperative Electrophysiology
The primary goal of this project is to understand the function of the motor control system in an established Parkinson disease (PD) rodent model using multi-channel electrodes. This includes studying the reticular formation, its connections and the role of these long tracts in controlling gait.
Projects Relating To Human Intraoperative and Postoperative Electrophysiology
A) In this DBS-PD project simultaneous intraoperative recordings of neurons in the subthalamic nucleus (STN) and of field potentials from motor cortex are obtained to allow us to understand the role STN has while patients perform cognitive and motor tasks.
B) A parallel project is studying long-term field potentials from STN recordings in PD patients post-DBS surgery. Patients will perform activities of daily living while real-time LFP data is collected.
Projects Relating To Neuromodulation and Diagnostic Devices
A) Post-surgical neuromodulation programming in PD patients is a challenge for neurologists. Extensive biomechanical data are being collected and studied in order to understand the impact of these settings on all aspects of mobility and activities of daily living.
B) Based on our pilot work we are studying the use of diagnostic sensors to guide drug therapy in existing and new patient groups. Many of these new applications/indications are done in partnership with industry partners from within Canada as well as